Publications

Click on the hyperlink for each publication below.

Ma L, Gilani A, Rubio-Navarro A, Cortada-Almar E, Li A, Reilly SM, Tang L, Lo JC. (2024). Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion. JCI Insight 2024 May 7;. [Epub ahead of print] [PubMed]

Gilani A, Stoll L, Homan EA, Lo JC. (2024). Adipose Signals Regulating Distal Organ Health and Disease. Diabetes 73: 169-177. [PubMed]

Yammine L, Picatoste B, Abdullah N, Leahey RA, Johnson EF, Gómez-Banoy N, Rosselot C, Wen J, Hossain T, Goncalves MD, Lo JC, Garcia-Ocaña A, McGraw TE. (2023). Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant. Molecular Metabolism. Epub 2023 Nov 2. [PubMed]

Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F, Posada V, Oxley PR, Cioffi M, Kim HS, Wang H, Lauritzen P, Boudreau N, Shi Z, Burd CE, Zippin JH, Lo JC, Pitt GS, Hernandez J, Zambirinis CP, Hollingsworth MA, Grandgenett PM, Jain M, Batra SK, DiMaio DJ, Grem JL, Klute KA, Trippett TM, Egeblad M, Paul D, Bromberg J, Kelsen D, Rajasekhar VK, Healey JH, Matei IR, Jarnagin WR, Schwartz RE, Zhang H, Lyden D. (2023). Tumor extracellular vesicles and particles dysregulate liver metabolism. Nature 618: 374-382. [PubMed]

Rubio-Navarro A, Gómez-Banoy N, Stoll L, Dündar F, Mawla AM, Ma L, Cortada E, Zumbo P, Li A, Reiterer M, Montoya-Oviedo N, Homan EA, Imai N, Gilani A, Liu C, Naji A, Yang B, Chong ACN, Cohen DE, Chen S, Cao J, Pitt GS, Huising MO, Betel D, Lo JC. (2023). A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nature Cell Biology 25(4): 565-578. [PubMed]

Nature Research Briefing of the study. See stories from the WCM Newsroom and the Cornell Daily Sun.

Stoll L, Lo JC. (2023). GLP-1 Receptor Agonists, the Holy Grail Preventing Atrial Fibrillation in Patients With T2D? JACC Basic Translational Science 8: 937-38.

Cortada E, Yao, J, Dundar F, Zumbo P, Yang B, Rubio-Navarro A, Perder B, Qiu M, Pettinato AM, Homan EA, Stoll L, Betel D, Cao J, Lo JC.. Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury. bioRxiv 2023. doi: https://doi.org/10.1101/2023.03.15.532865 [PubMed]

Ma L, Gilani A, Rubio-Navarro A, Cortada-Almar E, Li A, Reilly SM, Tang L, Lo JC. Alternative complement pathway regulates thermogenic fat function via adipsin and adipocyte-derived C3aR1 in a sex-dependent fashion. bioRxiv 2022 doi: https://doi.org/10.1101/2022.12.30.522320.

Reiterer M, Gilani A, Lo JC. (2022). Pancreatic Islets as a Target of Adipokines. Comprehensive Physiology 12(3): 1-27. [PubMed]

Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB, Gómez-Banoy N, Karakose E, Tanase M, Doridot L, Alvarsson A, Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart AF, Lo JC, Herman MA, Garcia-Ocaña A, Scott DK. (2022). Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure. Nature Communications 13(1): 4423. [PubMed]

Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Ma L, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Bhardwaj P, Piloco P, Rubio-Navarro A, Uhl S, Carrau L, Houhgton S, Redmond D, Shukla AP, Goyal P, Brown KA, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM, Lo JC. (2021). Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell Metabolism 33: 2174-2188. [PubMed]

See story from the WCM Newsroom.

Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu Longhua, Yu L, Wang L, He Y, Fan L, Hirawaka H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L. (2021). Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. Elife 10: e69209. [PubMed]

Stoll L, Lo JC. Is IL-1 the Bridge Connecting Type 2 Diabetes and Cardiac Arrhythmias? (2021). JACC Basic Transl Sci 6: 53-54. [PubMed]

Gómez-Banoy N, Guseh JW, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabon MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman G, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC. (2019). Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature Medicine 25: 1739-47. [PubMed]

Gómez-Banoy N, Lo JC. (2019). Adipokines as key players in β cell function and failure. Clinical Science 133: 2317-2327. [PubMed]

Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. (2018). Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci 115: 561-66. [PubMed]

Pabon MA, Manocha K, Cheung JW, Lo JC. (2018). Linking arrhythmias and adipocytes: insights, mechanisms, and future directions. Front. Physiol. 9: 1752. [PubMed]

You D, Nilsson E, Tenen DE, Lyubetskaya A, Lo JC, Jiang R, Deng J, Dawes BA, Vaag A, Ling C, Rosen ED, Kang S. (2017). Dnmt3a is an epigenetic mediator of adipose insulin resistance. Elife 6: e30766. [PubMed]

Gómez-Banoy N and Lo JC. (2017). Genetic manipulation with viral vectors to assess metabolism and adipose tissue function. Methods in Molecular Biology 1566: 109-124. [PubMed]

Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. (2016). A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function. Cell Metabolism 23: 454-66. [PubMed]

Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee-Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren P-O, Spiegelman, BM. (2014). Adipsin is an adipokine that improves b cell function in diabetes. Cell 158: 41-53. [PubMed]

Kong X, Banks AS, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng Y-H, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. (2014). IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell 158: 69-83. [PubMed]

Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi SP, Seehra J, Hawley JA, Spiegelman BM. (2014). Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157: 1279-1291. [PubMed]

Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JPG, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156: 304-16. [PubMed]

2005 to 2013

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. (2012). A PGC1α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481: 463-8. [PubMed]

Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Chatterjee-Bhowmick D, Ye L, Cinti S, Spiegelman BM. (2012). Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metabolism 15: 230-9. [PubMed]

Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM. (2011). Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase. Genes Development 25: 1232-44. [PubMed]

Lo JC, Wang Y, Tumanov AV, Bamji M, Yao Z, Reardon CA, Getz GS, Fu YX. (2007). Lymphotoxin β receptor-dependent control of lipid homeostasis. Science 316: 285-8. [PubMed]

Lo JC, Basak S, James ES, Quiambo R, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX. (2006). Coordination between NF-kB family members p50 and p52 is essential for mediating LTβR signals in the development and organization of secondary lymphoid tissues. Blood 107: 1048-55. [PubMed]

Zhu M, Chin RK, Christiansen PA, Lo JC, Liu X, Ware C, Siebenlist U, Fu YX. (2006). NF-kB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clinical Investigation 116: 2964-71. [PubMed]

Wang Y, Subudhi SK, Anders RA, Lo J, Sun Y, Blink S, Wang Y, Wang J, Liu X, Mink K, Degrandi D, Pfeffer K, Fu YX. (2005). The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clinical Investigation 115: 711-7. [PubMed]

prior to 2005

Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX. (2004). Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clinical Investigation 113: 694-700. [PubMed]

Lo JC, Chin RK, Lee Y, Kang HS, Wang Y, Weinstock JV, Banks T, Ware CF, Franzoso G, Fu YX. (2003). Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clinical Investigation 112: 1495-505. [PubMed]

Chin RK, Lo JC, Kim O, Blink SE, Christiansen PA, Peterson P, Wang Y, Ware C, Fu YX. (2003). Lymphotoxin pathway directs thymic Aire expression. Nature Immunology 4: 1121-7. [PubMed]

Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada K, Chen L, Fu YX. (2001). The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clinical Investigation 108: 1771-80. [PubMed]

Wang J, Chun T, Lo JC, Wu Q, Wang Y, Foster A, Roca K, Chen M, Tamada K, Chen L, Wang CR, Fu YX. (2001). The critical role of LIGHT, a TNF family member, in T cell development.  J Immunology 167: 5099-105. [PubMed]

Kim N, Bozek G, Lo JC, Storb U. (1999). Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. J Experimental Medicine 190: 21-30. [PubMed]