Publications

 

2018

Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. (2018). Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci 115: 561-66. [PubMed]

 

2017

You D, Nilsson E, Tenen DE, Lyubetskaya A, Lo JC, Jiang R, Deng J, Dawes BA, Vaag A, Ling C, Rosen ED, Kang S. (2017). Dnmt3a is an epigenetic mediator of adipose insulin resistance. Elife 6: e30766. [PubMed]

Gómez-Banoy N and Lo JC. (2017). Genetic manipulation with viral vectors to assess metabolism and adipose tissue function. Methods in Molecular Biology 1566: 109-124. [PubMed]

 

2016

Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. (2016). A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function. Cell Metabolism 23: 454-66. [PubMed]

 

2014

Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee-Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren P-O, Spiegelman, BM. (2014). Adipsin is an adipokine that improves b cell function in diabetes. Cell 158: 41-53. [PubMed]

Kong X, Banks AS, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng Y-H, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. (2014). IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell 158: 69-83. [PubMed]

Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi SP, Seehra J, Hawley JA, Spiegelman BM. (2014). Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157: 1279-1291. [PubMed]

Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JPG, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156: 304-16. [PubMed]

 

2012

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. (2012). A PGC1α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481: 463-8. [PubMed]

Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Chatterjee-Bhowmick D, Ye L, Cinti S, Spiegelman BM. (2012). Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metabolism 15: 230-9. [PubMed]

 

2011

Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM. (2011). Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase. Genes Development 25: 1232-44. [PubMed]

 

2007

Lo JC, Wang Y, Tumanov AV, Bamji M, Yao Z, Reardon CA, Getz GS, Fu YX. (2007). Lymphotoxin β receptor-dependent control of lipid homeostasis. Science 316: 285-8. [PubMed]

 

2006

Lo JC, Basak S, James ES, Quiambo R, Kinsella MC, Alegre ML, Weih F, Franzoso G, Hoffmann A, Fu YX. (2006). Coordination between NF-kB family members p50 and p52 is essential for mediating LTβR signals in the development and organization of secondary lymphoid tissues. Blood 107: 1048-55. [PubMed]

Zhu M, Chin RK, Christiansen PA, Lo JC, Liu X, Ware C, Siebenlist U, Fu YX. (2006). NF-kB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clinical Investigation 116: 2964-71. [PubMed]

 

2005

Wang Y, Subudhi SK, Anders RA, Lo J, Sun Y, Blink S, Wang Y, Wang J, Liu X, Mink K, Degrandi D, Pfeffer K, Fu YX. (2005). The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clinical Investigation 115: 711-7. [PubMed]

 

2004

Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX. (2004). Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clinical Investigation 113: 694-700. [PubMed]

 

2003

Lo JC, Chin RK, Lee Y, Kang HS, Wang Y, Weinstock JV, Banks T, Ware CF, Franzoso G, Fu YX. (2003). Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clinical Investigation 112: 1495-505. [PubMed]

Chin RK, Lo JC, Kim O, Blink SE, Christiansen PA, Peterson P, Wang Y, Ware C, Fu YX. (2003). Lymphotoxin pathway directs thymic Aire expression. Nature Immunology 4: 1121-7. [PubMed]

 

2001

Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada K, Chen L, Fu YX. (2001). The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clinical Investigation 108: 1771-80. [PubMed]

Wang J, Chun T, Lo JC, Wu Q, Wang Y, Foster A, Roca K, Chen M, Tamada K, Chen L, Wang CR, Fu YX. (2001). The critical role of LIGHT, a TNF family member, in T cell development.  J Immunology 167: 5099-105. [PubMed]

 

1999

Kim N, Bozek G, Lo JC, Storb U. (1999). Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. J Experimental Medicine 190: 21-30. [PubMed]